July 29 2017
Fungal Infections can be Tough to Eradicate
Ensure Complete Eradication with Itroze Caps (Itraconazole 100mg)
Itraconazole Capsules are an azole antifungal. It works by killing sensitive fungi.
Itraconazole – Clinical Pharmacology
Pharmacokinetic Characteristics: Peak plasma concentrations of Itraconazole are reached within 2 to 5 hours following oral administration. As a consequence of non-linear pharmacokinetics, Itraconazole accumulates in plasma during multiple dosing. Steady-state concentrations are generally reached within about 15 days, with Cmax values of 0.5 mcg/ml, 1.1 mcg/ml and 2.0 mcg/ml after oral administration of 100 mg once daily, 200 mg once daily and 200 mg b.i.d., respectively. The terminal half-life of Itraconazole generally ranges from 16 to 28 hrs after single dose and increases to 34 to 42 hrs with repeated dosing. Once treatment is stopped, Itraconazole plasma concentrations decrease to an almost undetectable concentration within 7 to 14 days, depending on the dose and duration of treatment. Itraconazole mean total plasma clearance following intravenous administration is 278 ml/min. Itraconazole clearance decreases at higher doses due to saturable hepatic metabolism.